The Effect of High and Low Antiepileptic Drug Dosage on Simulated Driving Performance in Person’s with Seizures: A Pilot Study

Crizzle, A., & Classen, S., LaFranca, C., Silver, W., & Eisenschenk, S. (2015). The effect of high and low antiepileptic drug dosage on simulated driving performance in person’s with seizures: A pilot study. The Open Journal of Occupational Therapy, 3 (4), article 3.


Antiepileptic drugs are used to control seizures, but have also been found to affect cognition, attention, and vision, which may impair driving. This study compared the use of high and low dose antiepileptic drugs on driving performance in persons with seizures. While no differences were evident in total or specific driving errors, higher doses were significantly associated with more lane maintenance and gap acceptance errors, suggesting that higher doses of antiepileptic drugs may adversely affect driving performance.